Check the list of Villains Here
Chapter 1.1 (Henchman)
Henchman: Triggering a Fury Buff #villain Attackers will passively Purify All debuffs
List of Villains that gain Fury Buff (Benefit from Henchnan Node)
| Champions | How to Get Fury |
| Annihilus | Replaces Stifled with Fury when Combo starter is Medium Attack |
| Carnage | Medium Attack |
| Crossbones | Just Fight Normally |
| Doctor Doom | Special 3 |
| Ghost | Heavy / Debuff Purify |
| Hela | Heavy / Special 1 |
| Juggernaut | 11% chance every hit |
| King Groot | Switches automatically |
| Magneto | Special 3 (only against Hero or Metal) |
| Mojo | Activating Anti-Life while he has at least 5M followers |
| Mordo | Heavy Charge |
| Red Goblin | Medium Attack |
| Rhino | End 5-hit combo with a Medium Attack |
| Thanos | 11% chance every hit |
| Ultron (OG) | Fight Normally |
| Unst. Colossus | 11% chance every hit |
| Venom | Special 2 Heavy to Randomize Buffs |
| Venom the Duck | Fight Normally |
| Void | Heavy Charge (With Hulk Synergy) |
Let’s Move to other chapters….
Chapter 1.2 (Genius/Madness/Mastermind)
Genius: While benefitting from at least 1 Armor up buff, #Villain Attackers will passively Burn 10% of the Defender’s Max Power on each hit, dealing direct damage based on the Power Burned.
List of Villains that can gain armor up buffs (Benefit from Genius Node)
| Champions | How to Get Armor |
| Doctor Octopus | Breakthrough Gives Armor Buff (Biology – Research Category) |
| Iron Patriot | 10% chance if receive hit |
| Killmonger | Fight Normally |
| Red Skull | Fight Normally |
| Sentinel | Special 3 |
| Unst. Colossus | 10% chance if receive hit |
| Ultron (Both) | Block Attacks (25% chance) |
| Venom | Start with Armor (use heavy if no Armor) |
| Venom the Duck | Fight Normally |
| Vulture | Permanent Armor |
Madness: When Triggering an Armor Break Debuff #Villain attackers will also apply a passive Powelock to the defender which will last until the last armor break ends.
List of Villains that can break armor (Benefit from Madness Node)
| Champions | How to Break Armor |
| Air-Walker | All Specials |
| Carnage | Heavy to Bleed Immune Champs |
| Cyclops | All Specials |
| Iron Patriot | Special 1 and 2 |
| King Groot | Heavy Attack (Use Heavy When Fury is Active to inflict permanent armor break) |
| Magneto | Special 2 Special 3 (If Robot) |
| Punisher 2099 | Special 2 |
| Ronan | Heavy Attack (Breaks only when armored up) |
| Sentinel | Special 1 |
| Taskmaster | Special 2 |
| Venom | Heavy Attack |
Mastermind: #Villain Attackers increase the duration of bleed, poison, incinerate, and shock Debuffs on the opponent by 100%
List of Villains that Apply Bleed, Poison, Incinerate, and Shock (Benefit from Mastermind Node)
| Champions | Debuffs |
| Abomination | Poison |
| Abomination (Immortal) | Poison |
| Apocalypse | Bleed |
| Carnage | Bleed |
| Crossbones | Incinerate |
| Doctor Doom | Shock |
| Green Goblin | Poison, Shock |
| Joe Fixit | Bleed |
| Killmonger | Bleed |
| Magneto | Bleed |
| Mole-Man | Bleed |
| Red Goblin | Incinerate |
| Red Skull | Shock |
| Sentinel | Shock |
| Storm (Pyramid X) | Shock |
| Taskmaster | Bleed |
| Ultron | Bleed |
| Ultron (OG) | Poison |
| Venom | Bleed |
| Venom the Duck | Bleed |
| Venompool | Bleed |
| Vulture | Incinerate |
Chapter 2.1 (Monster/Beast)
Monster: When triggering an unstoppable or unblockable Buff or Passive, #Villain Attackers will grant themselves a non-stacking Passive Regeneration granting 10% of their Max Health over 5 seconds.
Beast: When triggering an unstoppable or unblockable Buff or Passive, #Villain Attackers will cause the Defender to passively reduce their regen rate by 200%.
List of Villains that can go Unstoppable or Unblockable (Benefit from Monster and Beast Node)
| Champions | How to / When |
| Air Walker (Unblockable) |
Charging Heavy (If Fills a Bar of Power) Special 3 |
| Annihilus (Unstoppable) |
Fight Normally |
| Carnage (Unblockable) |
While Opponent Bleeding Or Amor Broken |
| Diablo (Unblockable) |
Special 2 |
| Doctor Doom (Unblockable) |
Special 1 Special 2 (When Aura Active) |
| Ghost (Unblockable) |
Special 2 (Needs Wasp Synergy) |
| Juggernaut (Unstoppable) |
After Every Special (Need Duped) |
| Killmonger (Unstoppable) |
When receiving Block Hit (After Special 1) |
| Kingpin (Unblockable Unstoppable) |
Unstoppable: Heavy Charge Unblockable: Special Attacks (When in overpower mode) |
| Magneto (unstoppable) |
Heavy |
| Mojo (Unstoppable) |
After Every Prompt is Complete (Need Korg or GHulk Synergy) |
| Mole Man (Unstoppable) |
When receiving Block Hit (While Monster Mask is active) |
| Morningstar (unblockable) |
Special 2 (Minimum 3 Soul) |
| Rhino (unblockable Unstoppable) |
Dash Attack |
| Omega Red (unblockable) |
% Chance on Basic Tentacle Hits (When Duped) |
| Storm (Pyramid X) (unblockable) |
Special Attacks (Minimum 6 Prowess) |
| Unst. Colossus (Unstoppable) |
After Every Special (Need Duped) |
| Venom (unblockable) |
Special Attacks (When Opponent below 18% Health) |
Chapter 2.2 (Overload/Tyrant/What’s Yours is Mine)
Overload: Each time a Buff is Nullified off the Defender #Villain Attackers gain an Indefinite Precession Passive increasing Critical Rating by 500.
List of Villains that can Nullify Buffs (Benefit from Overload)
| Champions | How to Nullify |
| Diablo | Counterflow Concoction |
| Doctor Doom | Heavy to Stagger L1 to Nullify Basic Hit While Aura is Active- Signature ability |
| Dormammu | Special 1 |
| Juggernaut | Heavy |
| Mojo | Special 1 |
| Morningstar | Special 2 |
| The Hood | Basic Attack Applies Stagger Special 2 |
| Venom | Special 1 |
Tyrant: #Villain Attackers cause 50% of their attack as bonus Energy Damage each time they hit their opponent or their block, as long as the Defender suffers from a Weakness Debuff.
What’s Yours is Mine: Whenever the Defender has a weakness Debuff applies to them, a Fury Buff with 60% of the Weakness’ potency is given to the Attacker for 5 seconds. While the Attacker doesn’t have a Fury Buff from this effect, the Attacker deals 75% less damage to the Defender.
List of Villains that apply Weakness Debuff (Benefit from Tyrant and What’s Yours is Mine)
If you don’t have Apocalypse, the best option is to enable Resonate Mastery. It will help you apply weakness using any champion. If this is something you don’t want to do, you can use other champions mentioned in the list.
| Champions | How to Apply Weakness |
| Apocalypse | Special 1 |
| Green Goblin | Special 1 Special 3 |
| Joe Fixit | Basic Attacks (In Spades Mode) |
Chapter 3.1 (Mixed from Previous Chapters’ Nodes)
- Henchman: Already Discussed Above (Under Chapter 1.1)
- Mastermind: Already Discussed Above (Under Chapter 1.2)
- Genius: Already Discussed Above (Under Chapter 1.2)
- Madness: Already Discussed Above (Under Chapter 1.2)
Chapter 3.2 (Mixed of All Previous Chapters’ Nodes)
- Henchman: Already Discussed Above (Under Chapter 1.1)
- Genius: Already Discussed Above (Under Chapter 1.2)
- Madness: Already Discussed Above (Under Chapter 1.2)
- Mastermind: Already Discussed Above (Under Chapter 1.2)
- Monster: Already Discussed Above (Under Chapter 2.1)
- Beast: Already Discussed Above (Under Chapter 2.1)
- Overlord: Already Discussed Above (Under Chapter 2.2)
- Tyrant: Already Discussed Above (Under Chapter 2.2)
