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John Mulaney’s Champion Challenge (also knows as Boss Rush) has 2 chapters. The first chapter allows you to do each path separately, but the second one force you to complete all paths in one go. All paths have the same champions but their health and attack increase as you progress.

Boss rush dec 2020

Top Counters to the Defenders

Howard the Duck

You need a champion that can nullify furies triggered by Rage Node. Also useful to nullify armors triggered by Explosive Personality. Here are the champions you can use

  • Black Widow Claire Voyant
  • Doctor Doom
  • Symbiote Supreme
  • The Hood
  • Or any other champions that nullify buffs


You need a Champion that either applies damage overtime debuff or gain power

  • Nick Fury
  • Hyperion
  • Vision Arkus
  • Sunspot
  • Venom
  • Guillotine 2099 (Can charge her to make Warlock easy)
  • Or any other that can apply debuff or gain power


Tech Champions gain fury that increases attack by 125%. You better use a Tech champion, but not necessary. It’s not mandatory but better to remove willpower and regeneration master to fight Warlock, else you will degenerate lots of health and your power will also be drained many times.

  • Vision Aarkus (Shatter Armor to shut down his ability)
  • Guillotine 2099
  • Star-Lord
  • Spider-Man (Stealth Suit)
  • Ghost
  • Hulkbuster
  • Captain Marvel Movie
  • Hyperion
  • Or any champ that you like. Can be done with almost any champ.


Just use a champion that can stop healing. Or any hard-hitter also works.

  • Warlock
  • Mysterio
  • Sentinel
  • Human Torch
  • Void


I used CMM for the first four paths but she failed to solo on the last 2 because of the high health pool.

You need a champion that is immune to Poison and can heal block (Masochism Healing). The best team to use

  • Sentinel
  • Mysterio
  • Warlock
  • Captain America Infinity War (200 Sigs) with Skill and Tech Synergy

Spider-Ham – The Boss

You need a champion that can stop evade.

When Spider-Ham Evades, you get a fatigue debuff on you. While fatigue debuff is applied, you suffer 25% of the defender’s attack each time you land a hit. Your 10% power is drained every second while it is applied. Additionally, each time your power empties to Zeo, suffer +240% of the defender’s attack as direct damage.

Here are the Top Counters;

  • Venom
  • Vision Aarkus (Just parry and wait for Cold Snap to apply)
  • Nick Fury
  • She-Hulk
  • Falcon
  • Or any champ that causes 100% ability accuracy or stops evade

What will be the best Team to use in the Second Chapter of this Boss Rush (John Mulaney’s Champion Challenge)

If you don’t have Captain America Infinity War ignore everything mentioned below

  • Captain America Infinity War (200 Sigs)
  • A Tech Champ (Sentinel or Mysterio or Warlock)
  • A Cosmic Champ (Vision Aarkus or Venom)
  • A Skill Champion (Nick Fury or Falcom or any good one you have)
  • A Mystic Champion (Black Widow Claire Voyant or Doctor Doom or The Hood or Symbiote Supreme)

What Champions to use against Defenders

If you don’t have Captain America Infinity War ignore everything mentioned below

  • Howard the Duck: Use the Mystic Champion You Brought
  • Gwenpool: Vision Aarkus or Venom or Nick Fury
  • Warlock: Vision Aarkus or Sentinel or Captain America IW or Black Widow Claire Voyant
  • Deadpool: Sentinel or Warlock or Mysterio
  • Mysterio: Captain America IW or Mysterio or Sentinel
  • Spider-Ham: Vision Aarkus or Venom or Nick Fury