The easy path for Story Quest Act 5.4.1
The Opponent Suffers a Permanent Degeneration effect losing 2% of their max health per second, but Lifestealing 125% of their Damage done.
The Champs you will be facing are
- Gwenpool (Stupefy)
- Yondu (debilitate)
- Ghost Rider (Power gain)
- Falcon (Debuff immune)
- Beast (Energy resistance)
- OG Vision (Armor)
- Quake (Stun immunity)
Then you will find different paths to choose, go for the one that has these champs
- Iron Fist (Bane)
The Boss: Punisher 2099 (25% power gain over 5 seconds, enhanced sp2, critical buffs, 108k health points)
So you are not likely to lose any health as long as you keep heating. Here is a video of the Life Transfer Complete Run.